"Massaetal.[5]demonstrated that in response to dextran sulphate sodium, CB1−/− mice produced a stronger inflammatory response in the colon than wild-type mice, suggesting that the endogenous cannabinoid system protects against colonic inflammation. In addition, colitis was reduced in mice when administered with a CB receptor dual agonist (HU210)[5]. Therefore the signalling of endogenous cannabinoid system is likely to provide intrinsic protection against colonic inflammation. These results could have important implications in terms of colon cancer prevention, since patients with inflammatory bowel disease (Crohn’s disease or ulcerative colitis) have an increased risk of developing colorectal cancer.Just one of the many reasons I support marijuana legalization.
CB receptors are cell membrane G-protein-coupled receptors that are linked through G i/o family of proteins to signal transduction pathways including inhibition of adenylate cyclase, activation of mitogen-activated protein kinase and regulation of calcium and potassium channels (reviewed in [3]).
Therefore the cumulative effects of CB receptor signalling are likely to have important implications in the control of cell survival and cell death with the potential for regulating tumour cell growth."
posted by dirtynumbangelboy at 8:55 AM on January 21, 2007