Unfortunately I don't have much to tell your friend about where to stay, given that of course I always stay with my family! I think the things to see in Antigua are pretty straightforward -- the ruins, the plaza, I'd certainly suggest he spend some time exploring the big market there, etc. And Panajachel is pretty touristy, so if he is the type to be turned off by that than he may want to see what he can find in some of the smaller towns around the lake to visit or stay in. I'd check out the Lonely Planet guidebooks -- I found them great on other trips I have been on, though I haven't seen the one for Guate. I think that they would provide good guidance overall on issues of safety and interesting opportunities.It's all pretty much in line with what others have said, but there's some good advice in there you can pick out.
Re travelling.. again, little personal experience there. But I think I would recommend that he hire a driver to take him from Antigua to Guatemala, or a tourist van. He should be able to find a decent driver at any upscale hotel -- it wouldn't probably cost that much, my memory was that hiring a driver to take me from Antigua into Guate City (45 minutes) was about $40... so maybe $100 to go to the lake? I could be wrong, but still a lot less than renting a car. But if he is needing to spend less, than I'd again find a reputable tourist transportation company through a guidebook... they know which roads to avoid and times to best travel. Guide books would also have ways to find good/safe drivers too I assume.
two other things...
TIKAL... a once in a lifetime experience that he shouldn't miss...
also see yesterday's USA today.
posted by MrMoonPie at 7:01 AM on March 4, 2005