Should I freeze my eggs?
May 29, 2018 3:10 AM   Subscribe

I’m 35 (nearly 36) and wondering if I should freeze my eggs. MeFites what are your experiences with this? Was the procedure painful? Did it result in a pregnancy? How old were you? I’m single and not sure if I would like children later on or not but don’t want to rule them out. I’ve been diagnosed with ‘borderline PCOS’ but apart from that am healthy- does the PCOS make a big difference? What do I need to consider? It won’t be cheap financially but I can afford it.
posted by EatMyHat to Health & Fitness (14 answers total) 7 users marked this as a favorite
 
Response by poster: I’m in Australia FYI
posted by EatMyHat at 3:11 AM on May 29, 2018


I've done the procedure that you would do in order to have eggs frozen (in my case it was to donate my eggs to someone else). Also in Australia, for what that's worth.

Pain isn't the main thing. It's massively disruptive to your life. You have to do a bunch of initial tests, and then you start taking hormones, first to suppress your natural cycle, then to get your ovaries to ripen as many eggs as possible, then finally to make them ovulate. The suppression medication is usually a nasal spray - it gave me migraines for about two weeks. This is a common side effect, but not everyone experiences it. Then the next medication is an injection that you do to yourself in the belly every day. It's not painful, just a bit icky. And you have to keep the medication at a constant cool temperature, and do it at exactly the same time every day, so you need to build your life around that for a bit.

The whole time you also have to have regular scans and blood tests (for me it was blood tests every three or four days for a month, and scans once a week). The final ovulation injection is bigger, and it hurts a little.

Within 24 hours of ovulation they operate to retrieve the eggs. You have heavy sedation/twilight anaesthesia for that, so it's not as bad as a general anaesthetic, but it is in hospital and you will have a few side effects probably. You go home within a couple of hours.

There was minimal pain for me associated with the retrieval - just achiness for a few days. Getting an IUD was way worse. But for the two weeks preceding it when my ovaries were really big with all the eggs, it was like the worst PMT ever, and my whole belly area just ached constantly. I couldn't ride a bike or even walk too fast (and wasn't supposed to exercise for a few weeks anyway in case of ovarian torsion). You can't have sex for most of the month, in case you accidentally get pregnant with quintuplets or something.

And there are risks of ovarian hyperstimulation syndrome, which is pretty common. I had it one time out of the three times I did this. It means you end up with huge amounts of fluid in your ovaries that has to be drained out, and you need to drink a lot of gatorade to keep your blood thin or something so you don't have a stroke. The risk is much higher for people with PCOS, and in fact, that's how I found out I probably have it too... On the plus side, people with PCOS usually react very quickly and easily to the medication, and they can give you a lower dose than other people. On the minus side, the doctor told me it is common for people with PCOS to produce lots of eggs (I usually had between 45 and 60 eggs retrieved - most women have 20 or so) but for them to be lower quality (about half of mine wouldn't fertilise at all, and fewer than 10 grew properly).

If I cared about having my own biological children, and time was running out, and if I had the cash to freeze my eggs, I'd probably do it. None of the medical side of it would put me off, even though my experiences weren't easy, exactly. It's definitely still easier than adoption, or finding an egg donor, or any of your other possible options later on.

But be aware that it also has a relatively low chance of success still. My friend's situation - egg donation from a then-mid-twenty-year-old (me) - had a pretty high chance of success. The clinic had success rates in the 80s for people in those circumstances within three rounds. But we rolled the dice and lost. The person I donated to only got pregnant once from all those eggs and embryos we produced, and she miscarried that one.
posted by lollusc at 3:30 AM on May 29, 2018 [8 favorites]


I have done IVF three times and the procedure is the same. This is UK, not sure how it may differ in Australia.

Before you even begin to think about retrieving eggs you should take blood tests to assess your hormone levels, specifically AMH. This will give an indication of your ability to produce eggs. If it is too low, your clinic may even advise that you do not go through with it. I am just telling you that you are prepared for this potential outcome because you are at the age where this is a real possibility. They also need to be of *excellent* quality to be eligible to be frozen. This also goes down with age.

The hormone injections to stimulate your follicles depend on what you need to take. I had two protocols for my various cycles: Gonal-F and Menopur, both on the highest dosage because my AMH levels were so low. Gonal-F was a breeze. The medication dispenser is super easy to measure and dispense and the needle was tiny. Menopur is more annoying as you have to mix two solutions and the needle is thicker. However, you inject these into fatty tissue (I did it on my stomach) and it's more psychologically disturbing than physiologically painful. I used a bit of ice to numb the area before and that was enough.

I did not have any emotional or physical side effects despite my high dosage. YMMV. Not only do you have to take these injections at the same time everyday but you will have transvaginal scans every other day to check on the progress of your follicles, so be prepared for your personal/work life to be disrupted for about 3 weeks.

When your follicles are big enough, you will be scheduled for a 'trigger' shot to release eggs. Follicle progress can be stressful. You want a lot and you want them to grow at the same rate. My body didn't respond very well and one of my cycles had to be abandoned. Ask your clinic about how payment works if your cycle must be abandoned. This is a real possibility.

Egg retreival can be a bit painful. It starts off like a pap smear. Then the doctor goes up with a needle to collect the eggs. The best way I can describe it is like if someone was scratching you inside with a sharp needle. I was under sedation and I was lucid enough to ask the nurse to increase my dosage when it got uncomfortable. My doctor was quick but like I said, I didn't have that many to retrieve anyway so again YMMV.

They will tell you that day how many they retrieved and how many qualify for freezing.

Successful pregnancy and birth is highly dependent on embryo quality, which is highly dependent on egg quality. That's really what it comes down to. If you have good eggs, you have good chances. I tried with my own good to mediocre quality eggs that weren't even frozen and was not successful. I am now pregnant from someone else's excellent egg that was frozen, fertilised, progressed to 6 day blastocysts, and then frozen again. It's not guaranteed of course, but my chances went from 20% to like over 50% when I switched to a younger, higher quality donor egg.

I have no regrets for the IVF cycles we tried but I wonder if we could/should have stopped sooner. But at the time, we felt like we just had to try if it was possible to have a child with my genes. But I also have no regrets about going with a donor egg. If you have any questions, please feel free to MeMail me.
posted by like_neon at 4:03 AM on May 29, 2018 [2 favorites]


If you’d like to read one woman’s first person account of this, Sloane Crosley’s recent collection of essays includes a long, very personal and honest account of her experience—the book is called Look Alive Out There and I believe it’s the last essay in the collection.
posted by bookmammal at 4:57 AM on May 29, 2018 [2 favorites]


I agree with like_neon that your first step is likely a fertility assessment to get a sense of where your baseline fertility is. I had my son via donor insemination when I was 33 & had probably the 'easiest' time of things since I was relatively young but it was still a lot of logistics to deal with.

I would also take a look at the rates of successful pregnancy that come from frozen eggs. At the time I was going though my cycle (now almost 7 years ago) the success rates for frozen embryos were much higher than the success rates for frozen eggs. My doc had explained it as pretty much a 'they've had more experience with embryos than eggs'. I'm sure they are better at eggs now but take a look at where they are now in terms of both successful pregnancies as well as successful actual babies being born.
posted by machine at 6:41 AM on May 29, 2018 [2 favorites]


There is an interesting episode of the podcast the Longest Shortest Time that talks about egg freezing. They also have a lot of informative links on their post about the episode.
posted by purple_bird at 9:27 AM on May 29, 2018 [1 favorite]


Also, it might be good to read this article on what can happen when you go to use frozen eggs. I was kind of shocked.
posted by purple_bird at 9:32 AM on May 29, 2018


I genuinely do not want kids, but if I had it to do over again, I would freeze my eggs. I'm going on 41.
posted by 8603 at 4:41 PM on May 29, 2018


Did it for IVF and was lucky to get pregnant on the first try. I was told that my test results were all above average for my age, and we had male problems which are much easier to fix.

I had a terrible reaction to the birth control pill which they put you on to start the process. And I had ovarian hyper stimulation, which caused a delay because I had to have a natural menstrual cycle one time to clear my system before they could go ahead. Then we did frozen embryo transfer, which I guess means I am anecdata for successfully getting pregnant with frozen eggs :-)

I have no regrets. We needed to do it because of my husband’s health needs, and I’m thrilled with my toddler son. I do have weird feelings about the remaining embryos though. We have eight unused embryos, and I don’t think I’m going to get pregnant again and am not really sure what to do with them. I don’t think I would be comfortable letting a stranger use them to have my genetic baby, but I don’t feel right destroying them either. I didn’t think I’d be so indecisive or emotional about this particular aspect until it happened.
posted by ficbot at 5:23 PM on May 29, 2018 [1 favorite]


Having ridden the infertility roller-coaster, and suffered the painful discussions of "well, for each year older you are, your egg quality decreases by x%" while simultaneously balancing the idea that this hugely expensive process has a single digit chance for success against my partner's rage and angst at the possibility of never having children, my advice is that if you have any inkling at all that you might want children but have no partner on the horizon you should go for it. The younger the eggs are, the more viable they are.

It's not a comfortable process, to be sure. You ramp up the hormones and you learn to give yourself shots (the desire for a successful outcome gets you right over any squeamishness). Retrieval is kind of like bad period cramps for a couple of days, you have to stay on bedrest but then you should be fine.

You will need to have a good hard look at what you will do with those eggs in five, six, seven years if you find yourself still partner-less. Will you feel compelled to use them just because they're there? Would you consider donating them to science (sorry to put too fine a point on it, but your eggs will be too old to donate to another infertile couple - generally speaking they only want early-20's and "proven" donors for donation). Would you be okay with having them destroyed, after having gone through the whole process and expense? Would you be okay letting go of them if you meet someone in six months and end up naturally pregnant a year from now? It's a lot to think about.

I've advised many times on AskMe to try to find a local meeting of RESOLVE, I met lots of women in varying situations regarding their fertility and I learned something from each of them. It would be good to try to go to a meeting and listen to their stories.
posted by vignettist at 6:23 PM on May 29, 2018 [1 favorite]


sorry to put too fine a point on it, but your eggs will be too old to donate to another infertile couple - generally speaking they only want early-20's and "proven" donors for donation

In Australia this isn't strictly true. Egg donation here is altruistic (no financial compensation allowed) so there are almost no donors and they will take just about whatever they can get. It's almost entirely known donors, too, of course, in these circumstances. So if you have a sister, cousin, or friend with infertility issues, they would be able to use your eggs even though you are in your thirties. It wouldn't be the preferred scenario, and a stranger with other options would probably decline, but it is a possibility. Especially since the eggs would already be there on ice and the only expense would be inseminating then and growing to blastocyst, which is relatively cheap to do. They'd know within a day or two if they were viable (ie growing normally) and wouldn't have to go further if they weren't.
posted by lollusc at 6:34 PM on May 29, 2018


I froze my eggs in the US, three cycles when I was 36.

I would say my life was pretty disrupted for about five months straight to do the three cycles. No exercise, very limited alcohol/caffeine, early morning blood work and ultrasounds every other day or so, and daily timed injections. I produced a LOT of eggs, and as a result, was bloated to the point of looking several months pregnant near the end (I couldn't button my jeans). Also, since you won't know the retrieval date till the last minute, you need your employer to be understanding and flexible about it. I just told my manager that I was going to have minor surgery one day that week and I wasn't sure which day yet. Calling in sick / chucking a sickie :) the day of the retrieval would work as well. You will need someone to take you home from the retrieval due to the anesthetic. It can also be helpful to have someone give you the final "trigger" injection, though I did it myself two of the times.

In my experience, it gets easier as you go. At first, I stayed home and fumbled with the injections (I was watching YouTube videos because I couldn't remember what the doctors had shown me) and I was super cautious and careful. Once I became comfortable, I'd pack my injection stuff with me to go out at night and inject myself in a public bathroom.

Pain: the injections hurt a very minimal amount, really not a big deal. As someone said above, the psychological/emotional effect of watching the needle go into my stomach was worse than any physical effect. Two of my three retrievals were fine, I was just very tired afterward (pro tip: really follow their advice to stay home and on bed rest till the following day rather than trying to get up and do things - apparently the recovery is much easier this way). I was in a lot of pain after one of the retrievals, very painful cramps, but medication and a heating pad helped.

Cost: when people discuss the cost of egg freezing, they always focus on the retrieval. But you have a bunch of doctor visits for blood tests and ultrasounds and those costs are a large portion of it as well. I chose a place that accepted my health insurance and it made a huge difference because I paid nothing for the blood work/ultrasounds. Likewise, the drugs for the injections are expensive, and you probably have a choice of where to get them. (I realize that you're in Australia and some of this cost advice may not apply, but it may apply to other future readers.) It's also worth mentioning that there's an annual fee to keep the eggs frozen and that fee varies widely from place to place.

Eggs vs embryos: someone said above that frozen embryos have a better success rate than frozen eggs because more is known about them. This isn't true. Embryos have a better success rate because they are less delicate than eggs and more likely to survive the freezing and unfreezing processes. So, one thing you should think hard about is whether you want to freeze just your eggs (for possible future fertilization by a partner or donor) versus fertilizing some or all of those eggs with donor sperm now and freezing them as embryos (to use in the event you never find a partner or your partner is infertile, etc).

I still don't know whether I will have kids but I'm glad I did this. It's not a guarantee of anything but it gives you a better chance of being able to have biological children in the event you decide you want to. And, although my life was disrupted and uncomfortable for a period, my body and life went back to normal afterward. Feel free to message me if you have questions.
posted by sunflower16 at 2:10 AM on May 30, 2018 [1 favorite]


I should clarify the timeline - I didn't spend the entire five months having ultrasounds etc. You have to take some downtime (at least a month) between each cycle. There's also no reason you need to do multiple cycles as quickly as possible. I just wanted to get it over with. I think it's maybe two weeks or so to get through the ultrasounds/blood tests, injections, and retrieval, then there's another couple of weeks afterward where you're still not allowed to exercise, if I recall correctly. So maybe a total of about a month of life disruption for one cycle. I did something like Cycle 1 + month off + Cycle 2 + month off + Cycle 3 = five months.
posted by sunflower16 at 3:09 AM on May 30, 2018


Also, I thought this was a pretty good account - it matches my experience for the most part:
https://www.elle.com/life-love/a14561/egg-freezing/
posted by sunflower16 at 11:46 AM on May 30, 2018


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