tightly controlled blood sugar and dementia
May 10, 2018 12:37 PM Subscribe
I was recently told that there is an association between tightly controlled blood sugar levels and future risk of dementia even when the blood sugar control is achieved through diet and exercise instead of medication., i.e. not associated with hypoglycemia or any acute low blood sugar episodes. I have not been able to find any data on this. Can you find anything?
I'm not sure that this is what you were saying you were told, but there is evidence that brain function is impacted by insulin resistance.
Alzheimer's Disease Is Type 3 Diabetes–Evidence Reviewed
"Type 3 diabetes" is used to refer to various possibly-unrelated things, but searching for that along with Alzheimer's and/or dementia might be helpful.
posted by substars at 12:48 PM on May 10, 2018 [1 favorite]
Alzheimer's Disease Is Type 3 Diabetes–Evidence Reviewed
"Type 3 diabetes" is used to refer to various possibly-unrelated things, but searching for that along with Alzheimer's and/or dementia might be helpful.
posted by substars at 12:48 PM on May 10, 2018 [1 favorite]
Findings from the Swedish Adoption/Twin Study of Aging: Diet-based glycemic load and, in particular, elevated blood glucose appear important for cognitive performance/cognitive aging. Blood glucose control (perhaps through low glycemic load diets) may be an important target in the detection and prevention of age-related cognitive decline.
posted by Iris Gambol at 12:52 PM on May 10, 2018
posted by Iris Gambol at 12:52 PM on May 10, 2018
I’m on a phone so I can’t link anything. Look up Dale Bredesen / Bredesen Protocol / The End of Alzheimer’s.
posted by ImproviseOrDie at 6:09 PM on May 10, 2018
posted by ImproviseOrDie at 6:09 PM on May 10, 2018
Another key word for your search in relating 'sugars' to 'dementia' would be:
Inflammation (brain)
posted by Halo in reverse at 6:40 PM on May 10, 2018
Inflammation (brain)
posted by Halo in reverse at 6:40 PM on May 10, 2018
Followup from the anon OP:
I am aware of the association between high blood sugar and dementia and have found studies backing that up. I have also found research studies associating over-controlled blood sugar that is achieved using insulin (and can therefore result in hypoglycemic episodes) and increased risk of dementia.posted by LobsterMitten at 8:38 PM on May 10, 2018
I was specifically told by a medical professional that there is an association between tightly-controlled blood sugar achieved through diet and exercise alone - with no hypoglycemia and no insulin or other tier 2 medications - and an increased risk of dementia. I have not been able to find any research supporting this and that's what I'm looking for.
”Women with type 2 diabetes had increased odds of poor cognitive function and substantial cognitive decline. Use of oral hypoglycaemic therapy, however, may ameliorate risk.”
posted by elisse at 7:39 PM on May 11, 2018 [1 favorite]
posted by elisse at 7:39 PM on May 11, 2018 [1 favorite]
This thread is closed to new comments.
The results of studies on the association of diabetes with the rate of cognitive decline vary, with the majority showing a higher rate or risk for cognitive decline in diabetic subjects compared with nondiabetic subjects , some showing no association between the rate of cognitive deterioration and diabetes status and others even showing a slower rate of decline in diabetic AD patients .
posted by gregr at 12:46 PM on May 10, 2018 [1 favorite]