tightly controlled blood sugar and dementia
May 10, 2018 12:37 PM   Subscribe

I was recently told that there is an association between tightly controlled blood sugar levels and future risk of dementia even when the blood sugar control is achieved through diet and exercise instead of medication., i.e. not associated with hypoglycemia or any acute low blood sugar episodes. I have not been able to find any data on this. Can you find anything?
posted by anonymous to Health & Fitness (7 answers total) 8 users marked this as a favorite

I'm not sure that this is what you were saying you were told, but there is evidence that brain function is impacted by insulin resistance.

Alzheimer's Disease Is Type 3 Diabetes–Evidence Reviewed

"Type 3 diabetes" is used to refer to various possibly-unrelated things, but searching for that along with Alzheimer's and/or dementia might be helpful.
posted by substars at 12:48 PM on May 10, 2018 [1 favorite]

Findings from the Swedish Adoption/Twin Study of Aging: Diet-based glycemic load and, in particular, elevated blood glucose appear important for cognitive performance/cognitive aging. Blood glucose control (perhaps through low glycemic load diets) may be an important target in the detection and prevention of age-related cognitive decline.
posted by Iris Gambol at 12:52 PM on May 10, 2018

I’m on a phone so I can’t link anything. Look up Dale Bredesen / Bredesen Protocol / The End of Alzheimer’s.
posted by ImproviseOrDie at 6:09 PM on May 10, 2018

Another key word for your search in relating 'sugars' to 'dementia' would be:
Inflammation (brain)
posted by Halo in reverse at 6:40 PM on May 10, 2018

Followup from the anon OP:
I am aware of the association between high blood sugar and dementia and have found studies backing that up. I have also found research studies associating over-controlled blood sugar that is achieved using insulin (and can therefore result in hypoglycemic episodes) and increased risk of dementia.

I was specifically told by a medical professional that there is an association between tightly-controlled blood sugar achieved through diet and exercise alone - with no hypoglycemia and no insulin or other tier 2 medications - and an increased risk of dementia. I have not been able to find any research supporting this and that's what I'm looking for.
posted by LobsterMitten at 8:38 PM on May 10, 2018

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