From a medical/science standpoint, what are the limiting factors that make it difficult to produce pharmaceutical drugs that do not have negative side effects?
posted by 6spd on Feb 17, 2013 - 22 answers

From a famous poem by Elizabeth Bishop.;....Even losing you,(the joking voice, a gesture I love) I shan't have lied. It's evident the art of losing 's not too hard to master though it may look like(Write it!) like disaster. The question is, what's the difference between " I shall never lie." and"I shan't have lied."??
posted by mizukko on Nov 29, 2012 - 10 answers

I'm looking to add some new music to my library, and I am fascinated with 'perfect albums'. [more inside]
posted by WinnipegDragon on Apr 14, 2012 - 119 answers

I need a new kettle. Be forewarned, my wife and I are over-thinking this like five plates of beans... [more inside]
posted by WinnipegDragon on Jan 26, 2012 - 35 answers

Do I have perfect pitch? [more inside]
posted by cronholio on May 10, 2010 - 34 answers

Help me find the perfect videogame for my boyfriend. [more inside]
posted by cobain_angel on Aug 18, 2009 - 39 answers