Asking for a friend: "There is some question about who my father is - the man who raised me (Daddy) or his brother (Uncle) The only family DNA I have is from my nephew who is my sister's son, definitely Daddy's grandson. My nephew and I share 1610 cM. Is this enough information to determine who my father is?"
I'm thinking of getting my genome sequenced by 23andme. However, I am not interested in a responsive, user-friendly experience. I want to get my raw data, upload it to Promethease, and also play around with it myself. I also have some privacy concerns, and am wary of the family/ancestry features. Help me think this through. [more inside]
Two part question. First - my family strongly suspects my father has late-stage Pick's Disease, which is a form of fronto-temporal dementia. It can't be truly diagnosed until an autopsy though. He's post-65. He has most of the symptoms. So I have two very related questions. [more inside]
I've just been reading a review of the latest film treatment of Alzheimers ("Still Alice"), which has the character inherit her early-onset version of the disease from her alcoholic father. But at least for a while, it seemed like the medical thinking linked Alzheimer's to mitochondrial DNA, so that it would be linked to the mother's genetic profile. I realize that it's a hideously complex disease, with or without alcoholism as a factor, but is the maternal-line theory valid?
I'm gearing up for a final exam in my undergraduate level genetics class, and I'm finding my textbook (iGenetics by Peter Russell) and the professor's slides are not sufficient for my study needs. I'd really like some more sources to review over the next few days. The topics on this final exam are operons, conjugation/transformation/transduction, genomic imprinting, and differential gene expression. Do you have any favorite online resources for studying these subjects? The more specific the better (i.e. a specific youtube playlist or a specific section of a website, rather than just a generally genetics related channel or site).
Can you help me find pieces of medical terminology named after women, or female medical eponyms? I'm talking about anatomical structures, diseases, conditions, collections of symptoms - hell, even proteins or genes would work! Wikipedia has a list of human anatomical parts named after people, but none of the people listed appear to be female. [more inside]
My mother is convinced she is the product of an incentious relationship by her mother and her grandfather. Genetic testing proved inconclusice due to the poor quality of the samples available from her grandfather (my greatgrandfather) and her mother (my grandmother) as both were deceased by the time the testing was done. My parents are first cousins (my maternal and my paternal grandmothers are sisters). I have a child by my SO (not a relative). I constantly worry for his long-term health. This whole issue was extremly worrying to me during pregnancy, but I expected my worries to decrease once he is older, and especially as he continues to develop fine physically and mentally, developing right on target. He will soon turn 6 and I worry more than ever, every little quirk gives me sleepless nights. [more inside]
For years, I've assumed I was 1/32nd Native American. I've seen a picture of my great-great-grandmother, who's clearly part Native American. The story was always that she was half. That would make my great-grandfather a quarter, my grandmother 1/8th, my mom 1/16th and me 1/32nd. Except that when I look at 23andme results, there's no indication of that in my ancestry composition. Native American comes in at 0.0%. Is there a chance my results could be off?
How quickly does genetic drift lead to speciation in higher life forms? More specifically, how long would it take for two isolated human populations, exposed to similar but not identical selective pressures, to become incapable of producing viable offspring due to genetic drift? [more inside]
My relative wants to take a 23andMe DNA test, but he has a heart and a kidney transplant (from 5 years ago). I have read about the possibility of chimerism (which I understand to be the presence of two sets of cells) in transplant recipients, and I am wondering if such a condition would affect the saliva-based DNA testing of 23andMe? And also, how common is this condition in transplant patients? Is there only really a pretty small chance that this will affect his test?
Chatting casually with a bioinformatician yesterday, I was told that I have 99% chance of developing Alzheimer’s disease, based only on my mother and father’s nationalities. How should I take this claim? [more inside]
You Are Not My Genetic Counselor, But Neither Are Any of these Self-Styled Uncertified Genetic Counselors on the Internet. The latest fad/quackwatch for desperate parents and patients dealing with autism spectrum disorders or chronic illness seems to be running raw data from consumer genetics testing through an app (or paying hundreds of dollars more for a "nutrigenomics" panel) to check for polymorphisms. Consumers get back lists (helpfully color-coded like traffic lights) of normal, heterozygous, and homozygous gene pairs, but how common are these variations to begin with (setting aside how often they are actually expressed as illness)? [more inside]
I saw a license plate that said CCA TGG, and I was wondering if this is a clever pun by a geneticist. [more inside]
Biologists and Staticians... what's going on here? There hasn't been a female born in my husband's family in two generations. Help solve the brothers' debate about what's causing this, and what the odds of our pregnancy being male or female is. [more inside]
Does anyone know about any research that shows that the meaning of symbols is passed down genetically? [more inside]
Please recommend some up-to-date textbooks in genetics and immunology. [more inside]
Is 23andMe sufficient for the genetic testing my fiance and I require before getting married (Jewish genetic testing)? [more inside]
Hi, I am hoping to get to the bottom of something that has been driving my nuts ever since I was a kid. I have hypersensitive skin to touch. It turns red (or sorta faded yellow/white) the second it is pressed. If I poke my arm with a finger I can see a circle that fades from red, yellowish to white and then it goes back to normal. All within 10-15 seconds. I noticed it being annoying whenever I went for a haircut and scissors glided along my forehead. It would leave a red mark for the next 5-10 minutes. Secondly whenever I went in for a massage, the therapist would joke that I bruise easily and turn red within a second of being touched. Could my blood type be the reasoning behind this? I am ' A- ' and I am just taking a wild shot at dark here. Was hoping someone with experience could clue me in to why my skin acts the way it does. My roots are predominantly southern-european with some distant Turkish/Ottoman ancestry. Green eyes and moderately white skin complexion. I'm not Irish-white by any means but white like most southern Europeans. Thank You for your insight!
Asking for a friend. In a nutshell: My friend has been contacted by at least two different people seeking to identify their biological father, a sperm donor. My friend has enough information to make an educated guess about the identity of the sperm donor. How should he proceed? [more inside]
This question has several parts, so please bear with me while I suss it all out. I have a specific question about inbreeding, and an open ended one about selecting traits in animals in general and honeybees in specific, though anyone familiar with genetics and animal husbandry can help me here. [more inside]
I'm trying to determine whether my dad is really my dad. I have my DNA raw data and my dad's raw data from 23andme, but results are not yet calculated for relatives. [more inside]
My boyfriend and I haven't been together for a very long time, but it has already started to feel very serious and I see the potential for a longterm future together. We are both extremely close with our families and I know that family life and children are a huge priority for both of us. We're on the same page there. However... By extraordinary coincidence we both suffer from the same rare, semi-inheritable disease. [more inside]
I saw a trailer a while (1,2 years?) ago. The plot had something to do with either a company or research project that had gone wrong. Genetically messed-up creatures and people were roaming around inside an office block. In the trailer, a guy is at the photocopier, and a large, human-faced spider thingy creeps up behind him. [more inside]
How can you tell the physical and chemical structure of a nucleic acid based on a sample's proportions of nucleotides? [more inside]
I know I want to study genetics but I don't know where to go from there. What kind of things in genetics did Professor X and the Drs. Suresh on Heroes study? I want to study that. [more inside]
Genetics and schizophrenia, what are the risks in having children? [more inside]
Career mashup: Genetics Research and Networking. [more inside]
How can I learn enough about biology and genetics to understand current research into cystic fibrosis? [more inside]
Was reading about microchips that are designed to allow a few mistakes (known as 'Sloppy Chips'), and pondering equivalent kinds of 'coding' errors and entropy in biological systems. Can a fair comparison be made between the two? [more inside]
Have any of you participated in or led the genetics lab using fruit flies? [more inside]
Why do African violets not propagate "true," in regards to color patterns? [more inside]
What are my options for secretly determining paternity? It's come to my attention, thanks to some casual conversation about blood types, that my blood type is possibly incompatible with my parents'. This is not something I want either parent to know I know, until I'm damn sure. [more inside]
Can you ever really change your body shape with specific exercises? [more inside]
Looking for an awesome primer on genetics! It should start somewhere around the highschool level, and continue through to some college-level material. Bonus points if it touches on some recent developments and research. Oh! And readability is key. [more inside]
If personality isn't supposed to be genetic, then how are pet breeds able to be differentiated by personality? [more inside]
Which X Chromosome did I inherit from my mother? [more inside]
A question for all the molecular geneticists out there: how did you go about setting up your first lab? [more inside]
Questions about biology, genes, humans and apes, courtesy of the movie Rise of the Planet of the Apes. SPOILERS WITHIN. [more inside]
After seeing my mother suffer from myriad health problems due to her depression and obesity, I am freaking out that my destiny is written in my genes. Please help figure out how to change the things I can and accept the things I cannot. I also welcome stories/advice from children of unhealthy people who learned from their parents' mistakes. [more inside]
Do my kittens have two dads? They come from the same litter but have different hair length. [more inside]
I don't know enough about genetics generally, and RNA specifically, to work through this Star Trek RPG story hook. Please hope me. [more inside]
How common is human chimerism of the sort described in this Boing Boing post? What implications does the existence of chimerism have for DNA testing, especially with respect to the criminal justice system? Does it pose a practical limit on the usefulness of DNA evidence, or just a theoretical one? Has chimerism come up in any cases, or been considered as a problem in legal scholarship?
My poster group needs a short, snappy title (preferably with a terrible newspaper style pun). And we've got nothing. [more inside]
[biogeography filter] Both of my parents are adopted. How can I find out more about my ethnic heritage? Complicating factors inside. [more inside]
Trying to find an NPR program about an eccentric pioneer of genetics who insisted on black laboratories? [more inside]
YANMD but: can a bald patch in the beard be an indicator of oral cancer? More detail below. [more inside]
A late friend of mine had a very rare genetic disability, which he never liked to go into great detail about. I'd like to know what it was. The condition had some very distinctive characteristics. [more inside]
How do I go about learning how DNA sequencing works? [more inside]
Life with (and without) Huntington's. [more inside]
Looking for books on genetics, archaeology, and anthropology for a 14 year old interested in history and non-fiction. [more inside]
Page: 1 2