Tomasetti and Vogelstein recently published an analysis that suggests the variation in the number of stem cell divisions leads to cancer incidence rates that are higher for tissues with relatively greater numbers of divisions. They recently posted a follow-up which attempts to address some of the counterarguments to their results. Acting on the premise that their work is correct or at least "in the right direction", are there labs or drug companies working on gene therapies that attempt to improve DNA polymerase fidelity (even in model organisms), as a means to one day perhaps reduce cancer incidence in higher-risk tissues? While it is easy through mutagenesis to worsen fidelity rates and increase cancer rates (as has been demo'ed in mice, say) can this aspect be engineered to be improved — that is, what biochemical aspects of (human) DNA polymerase have evolved to control its fidelity rate such that it might be possible to improve upon it?
Imagine a large bird like an ostrich. Could its breath fog up a window? We are watching Jurassic Park and wondering if the raptors' breath could fog up the window in the kitchen door.
My +1 is outfitting the molecular biology and biochemistry side of a physics lab. He would like to get books (electronic and/or paper) to fulfill two needs: 1. protocols and reference - for in lab use 2. history or textbook of molecular biology - to help familiarize physics people with the field. Looking for suggestions for solid books that are readable and have good figures. [more inside]
Please don't tell me I made this up; it's one of my favorite factoids. I remember hearing a radio piece, back in maybe 2011, about the effect that stress has on the tips of neurons. [more inside]
I will soon be the proud owner of a PhD in neuroscience and pharmacology, and I still love scientific research, but I don't know where to go next. [more inside]
Calling all marine biologists! Question about whales and their health inside. [more inside]
I need 8 or more hours of sleep a night, and some people need 6 or less, and I'm having a hard time dealing with the fundamental unfairness of this, and the fact that it seems like they have a huge advantage in life. I need insight from other people: emotional, practical, or scientific. [more inside]
What is this part of a lobster claw called (the white fan-like projection that is normally inside the musculature)?
I weigh myself every weekday at work on the same scale (an electronic medical-grade scale they use for patients at the hospital where I work) and at the same time of day. I have noticed that when I go off my diet for a few days and my weight creeps up, that that excess weight falls off again when I return to my diet much more quickly than the weight I've been carrying for awhile. Why? [more inside]
Can you identify what animal this (1, 2, 3) bone is from? It was found washed up on a beach in Rhode Island. [more inside]
I am looking for research/articles/papers on people's instinct to sacrifice for the "greater good". I have read an article mentioning John Bowlby and a term called "collective protective instinct", but outside of said article I haven't found any mention of this term. [more inside]
I'm beginning a project that looks partly at biological classification, primarily in western science. I have no background in this, and so I'm digging around. I'm interested to know more about the current rules for nomenclature, and also to know more about historical, philosophical, sociological, knowledge practice, ethnographic, anthropological, science technology and society (STS), sociotechnical, etc., approaches to the study of biological classification. I'll take monographs, articles, papers, web sites, etc. I have access to a university library. What are some good sources that can introduce me to this? Many thanks!
Open to any and all recommendations on the most efficient way to study for the GRE (focusing on writing and grammar). My GPA in college was meh (3.0). So I really need to have a nice shiny test score to go along with my floating-by transcript in order to get into top choice schools. Any advice on courses, sites, studying regimens etc. to go into this thing as ready as possible? [more inside]
I remember an old roommate told me that she had a job in a medical lab with a bachelor's in art history (not related to lab work). I have an Associates in Arts degree and am working on my bachelors degree in Clinical Laboratory Science. I will start volunteering at the medical lab in the hospital on Thursday. Are there any jobs in the lab for people like me? Maybe after I've volunteered for a few months? Thanks.
Ideas for growing a plant, at home, in an artficially created atmosphere that has a lot more CO2 than normal - for a science project ? [more inside]
It's spring and the plants and trees which have been bare for months are bursting into life. I've been thinking it must take a lot of energy for a tree to go from having no leaves at all to being covered in too many to count in a relatively short period of time. But how much energy exactly? [more inside]
I'm a sophomore biology major but I want to get internships in consulting firms or pharmaceutical companies, both of which are coming to my school tomorrow for career fairs. Unfortunately, I'm a biology major which isn't necessarily the most marketable major in the world. My experience is mainly through clinical research and I held three jobs last summer but none of them are related to the internships I'm looking for. [more inside]
Biologists and Staticians... what's going on here? There hasn't been a female born in my husband's family in two generations. Help solve the brothers' debate about what's causing this, and what the odds of our pregnancy being male or female is. [more inside]
To ask the question another way, why are modern land vertebrates so small? If it's to do with environmental factors, which ones? [more inside]
What happens to the drinking water I swallow? All I know is that it goes down my throat to my stomach, and then my body does its thing. Can you go into greater detail for me? For example: What positive effects does the water I drink have on my mouth, my throat, my stomach and other parts of my body? How does the stomach process the water? Where does the water go after my stomach? How does what's in the water get from my stomach to the necessary parts of my body? What's in water that my body needs? What parts of my body benefit the most from the water I drink? Feel free to answer other relevant questions that I've overlooked.
My mom is 65. She's been teaching math & science at a high school for years. She's getting ready to retire, and would like to work (not just volunteer) part-time for a few years. Tutoring is an obvious choice. But she'd rather explore something else. What other part-time gigs might be a good fit? Of note: she is a total badass. Super sharp. Athletic. Loves to travel. Has been known to take off on long bike adventures/kayak trips/etc. Seeking something delightful to feed her mind/body. [more inside]
Please recommend some up-to-date textbooks in genetics and immunology. [more inside]
I am interested in what hormonal differences exist between men and women and what effect this has on behavior. I don't have the biology background to be able to handle a textbook. This is a contentious area, so I'm only interested in claims or resources that are well referenced - not unsupported pop-sci or ideological claims. My level of detail would be an extended blog post or article, rather than a book
I'm looking for a low-cost app or site where you can explore the muscular structure, how they attach to the skeleton, isolate a muscle by turning on/off other muscles, etc. My chief aim is for fitness purposes so I can understand my own body better before my chiropractic visits. Book or other learnig tool recommendations are welcomed! [more inside]
Iam thinking of gift idea for the scientifically minded specifically Biology, even better Microbiology. It's for a SO who just enrolled in Phd program in a reputable university. She already has the microbe/parasite pillows. Any suggestions?!
How long will a spider, trapped in a car, take to die? [more inside]
I'm on a course of antibiotics, so I'd like to begin re-colonizing myself with some helpful gut flora. Totally willing to get whatever from wherever; there are Whole Foods and various hippie stores (no slight intended) around where I can purchase food or pills, if I need something not available at a mainstream big box retailer or grocery store. [more inside]
This seems like it ought to be a simple question but I'm not finding the answer myself. Someone here must already know. I would like to buy sheets of printable adhesive labels suitable for sticking on 1.5ml/2.0ml microcentrifuge tubes. Ideally I would like both dots for the caps and little rectangles for the sides. They don't need to be able to stand up to particularly tough conditions, except that they shouldn't run if they get wet. Also, they should be cheap as I am a grad student and would be buying them out of my own pocket. I am just sick of writing the same teeny tiny letters over and over and over again with an ultrafine Sharpie. Can somebody here point me to a product that I can buy that would suit my needs? [more inside]
I'm looking for two books, one biology, one chemistry. They are related to GCSE, they say that on the front of the books, but I don't know if they're licensed. One has a green cover, one has a blue cover, but they both have pictures on the front. The good thing about these books is that they explain scientific concepts through diagrams in one-pagers, which are conveniently in both Chinese and English. Help me find these books? [more inside]
My brother and I explored an old mine and found these moths with white spiky protrusions lining the walls. At first I thought they were some kind of extending water-gathering device (they are covered in condensed drops), but then I realized that these moths were all dead. The place was a veritable mautholeum. The stuff now appears to me to be some kind of fungus — could it be the dreaded Cordyceps in our back yard? Or is it something less exotic?
Last week the kids and I explored lots of tide pools in Maine and found all sorts of interesting things. But there were some organisms firmly attached to the underside of rocks that I am unable to identify. They looked like clear discs of tough jelly, with a star-like pattern inside, and were all about a half a centimeter in diameter. Here's a photo that you can zoom in on to see them - they are near the bottom edge of the rock in the pic - zoomit link. (Also - is that a mass of eggs next to one of them as well?)
I seem to recollect an eye tracking experiment comparing the female body parts prioritised by men and the male body parts prioritised by women when looking at a stranger. Where is this recollection coming from? What is this study? [more inside]
I want to write a science fiction story where somebody spends a few weeks or so living off a food that was intended for people colonising another planet, with odd effects. I'm not that scientifically knowledgeable and I want this to be grounded in facts. More details below. [more inside]
I really love biology, especially ecology and conservation. I don't want to go straight into grad school, and I don't daydream about being a professor or teacher. What can I do between now and May 2014 to make myself a competitive job applicant? What jobs are available and realistic? Where can I find them? No one in my family is a scientist, so I have no idea what I'm doing. [more inside]
How accurate are TV shows and movies in their portrayal of cutting throats and lopping off limbs? [warning; Game of Thrones spoilers] [more inside]
I'm looking for the best marine biology summer camp for my sibling who will be 14 in the summer of 2014. Or the resources to find one. [more inside]
Please help identify this tree. The photo was taken in Vancouver yesterday.
Looking for videos to create a youtube playlist to entertain a group of science-minded teenagers for about 30 min that are largely visual. Sound is fine but the bulk shouldn't be someone talking to the class like an instructor - visualizations are best - ideally they should look really, really cool. Class is engineering focused, but chemistry, robotics, wobbly bridges, comp-sci, biology, are all welcome. [more inside]
I'm wondering if anyone can shed some light on the daily experience of a university researcher in either psychology or the basic sciences as well as a meta-review of the job as a whole. [more inside]
What is this thing my cat brought to my porch? http://i.imgur.com/cejZcGe.jpg It appears to be something between an animal fetus and organ. When I turned it over it looked the same on the other side. There were no visible eyes/mouth/features. It was larger than a quarter and there was no blood present. A possum visits regularly, and the area has many moles, birds, and raccoons.
What is the longest amount of time a single cell (whether on it's own or in an animal/plant) can live without either splitting or dying? [more inside]
I'm trying a analyse a set of biological data for a research project and I'm having trouble finding the appropriate statistical tests to use. [more inside]
I recently accepted a sales position within a company that sells laboratory equipment. (i.e. centrifuges, GC's, HPLC's, Thermal Cyclers, etc) I have no previous lab or science experience, so learning about a myriad of highly technical products/methods is a quite challenging. My main challenge comes from the fact that I need to engage in conversations with scientists, chemists, biologists on a daily basis. With no previous lab experience, I've been having a hard time talking to them on technical level. [more inside]
What are some non-institution-specific scholarships or grants for someone who wants to do primate research this summer? [more inside]
We're buying a house (still negotiating, hence the anonymity), and we have learned that the level of lead in the water is slightly above the expected range. Not knowing whether this is a big deal, I've tried to do some math to figure out whether being over the threshold is an object of legitimate concern (or whether the range is the fruit of a hyperactive regulatory state) and the process has led me to even more questions. [more inside]
What statistical test should I use to determine if there is a significant difference in the percent change in the presence of bacterial species observed among five groups before and after treatment. [more inside]
Need some biology based phrases of encouragement for a poster. [more inside]
Science grad school application filter: I have informally (but explicitly) accepted a graduate assistant position (in conservation biology) at my current undergraduate institution. I am now having second thoughts and am wondering what, if anything, I should do about it. Help me, Hive Mind! I don't know what to do! [more inside]
Lab workers: With which brand of pipette driver / pipettor should we stock our lab? [more inside]