44 posts tagged with biochemistry.
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Lower temperature methyl cellulose

Methyl cellulose solution has the handy property of being liquid up to about 50deg C, and becomes solid(ish) above that temperature. I'm looking for a substance that does the same, but with a transition temperature somewhere around 0-20deg C. [more inside]
posted by metaBugs on Jul 25, 2016 - 9 answers

Just the nutritious facts, ma'am.

I'm looking for the best book (or other source) on nutrition. Not a diet book. Not anything with an opinion (to the extent that's possible). I just would like to read a book that describes what's going on with our bodies and the foods and nutrients we put into them. How exactly are the major nutrients metabolized? In what order over what time period? What are the functions of the various amino acids? What do the various vitamins and minerals do? And so forth. I just want to know what's going on, because I can't read a thousand diet and exercise books all pushing some points over others. I have a technical background, so I can handle and appreciate decently-complex explanations of biochemistry and the like. In fact, I like that stuff. Just as long as it starts at the beginning and builds up to that. So just, the cold, hard, comprehensive facts on nutrition, please. [more inside]
posted by KinoAndHermes on May 17, 2016 - 14 answers

Given the Taubes/Lustig view on sugar, why not use dextrose everywhere?

If we assume the (increasingly accepted) view that sugar, in any decent quantity, is a highly unhealthy thing to eat, and that the main culprit is actually fructose, is there any good reason to not aggressively replace sugar or HFCS with dextrose? [more inside]
posted by tempythethird on Apr 7, 2016 - 10 answers

Testing "stepwise" biochemical affinity for multimers?

How would you test whether the affinity of a tetramer for a particular ligand proceeds stepwise, i.e. assuming that the tetramer can bind one ligand per subunit, how would you test whether an initial binding event made subsequent binding events on the same tetramer more likely? I can't think of a good way to isolate a single molecule in solution, so any experiments would have to be on a aggregate population which would make stepwise cascades in affinity impossible to measure. Maybe if the measurement was really really time sensitive? Thoughts?
posted by nicolas léonard sadi carnot on Dec 4, 2015 - 3 answers

Course/Materials: Chem/Biochem meets Sustainability?

Is anyone aware of an upper-division undergraduate or masters level course - or materials for such a course - with the following criteria. The course should describe, holistically, both scientifically rigorous descriptions of chemistry as well as sociological/anthropological implications of this science that illustrate the intersections of chemistry/biochemistry with sustainability. [more inside]
posted by anonymous on Sep 26, 2015 - 5 answers

What next for a biochemistry / physiology PhD?

I'm a couple years off finishing a PhD that's been about half biochemistry and half electrophysiology at a top-ranked Australian university. The academic career path is definitely open to me - I've got a decent number of publications, heaps of teaching experience, blah blah blah - but I'm unsure that it's what I want to pursue. [more inside]
posted by nicolas léonard sadi carnot on Mar 1, 2015 - 3 answers

About DNA polymerase...

Tomasetti and Vogelstein recently published an analysis that suggests the variation in the number of stem cell divisions leads to cancer incidence rates that are higher for tissues with relatively greater numbers of divisions. They recently posted a follow-up which attempts to address some of the counterarguments to their results. Acting on the premise that their work is correct or at least "in the right direction", are there labs or drug companies working on gene therapies that attempt to improve DNA polymerase fidelity (even in model organisms), as a means to one day perhaps reduce cancer incidence in higher-risk tissues? While it is easy through mutagenesis to worsen fidelity rates and increase cancer rates (as has been demo'ed in mice, say) can this aspect be engineered to be improved — that is, what biochemical aspects of (human) DNA polymerase have evolved to control its fidelity rate such that it might be possible to improve upon it?
posted by a lungful of dragon on Jan 21, 2015 - 3 answers

Could I be resistant to all opioid drugs?

Biochemistry Filter: I believe I have some kind of resistance/insensitivity to opioid painkillers, although I have not been able to verify that this is a medically known phenomenon. I am due to give birth soon, and I am concerned with the possible efficacy of drugs that may be administered for labor pain. Do you have any experience with this in yourself or others, or can you comment on the chemical plausibility of it? [more inside]
posted by zadermatermorts on Dec 20, 2012 - 20 answers

What to get for a classical-music and science-loving mentor as a present?

What to get as a going-away present for my classical-music-and-science-loving mentor when I make a great deal less money than them and don't have as much knowledge as them in their interests? [more inside]
posted by schroedinger on Nov 21, 2012 - 10 answers

Best pipettors for a biology lab

Lab workers: With which brand of pipette driver / pipettor should we stock our lab? [more inside]
posted by metaBugs on Nov 3, 2012 - 7 answers

So long, and thanks for all the genetically modified mice

What non-academic career paths are open to a freshly-minted biology PhD? [more inside]
posted by qxntpqbbbqxl on Jun 9, 2012 - 10 answers

Do you know anything about City College of San Francisco's biotech/computer skills certificates?

Has anyone completed the "Genomics Technology," and "Computer Skills for Scientists" certificate programs at the City College in San Francisco? My plan is to take these classes while finishing up pre-med requirements at the City College. Then I want to find a job in genetics research while I decide between medical school/finishing my biochem education at Berkeley. Is this feasible? Is this a good plan? [more inside]
posted by sunnichka on Mar 8, 2012 - 7 answers

How many generations of cells could now exist from a single sample taken in 1972?

If a sample of cells was taken in 1972, reproduced in laboratory by cell division to create a cell line used in science today based originally on the sample, what "generation" of cell would be used today, and how far back in history BC/E would a comparable human generation be? Is that even calculable? [more inside]
posted by Quarter Pincher on Mar 6, 2012 - 12 answers

How many Watts before a swat?

How is it that a tiny housefly has enough energy to drive me mad by flying around my house for an hour or more? How long could it keep going?
posted by rongorongo on Jan 11, 2012 - 2 answers

How did you plot your scientific career path?

Biologists, biochemists, and microbiologists: how did you choose your field? I'm coming to the end of my undergraduate research year, and hope to apply for doctoral study for 2013, but am finding it very hard to settle definitively on a field and a lab to target. If you were a bright young thing about to start your research career in earnest, where would you hope to end up? [more inside]
posted by nicolas léonard sadi carnot on Jan 4, 2012 - 8 answers

GRE Biology Subject Exam question

Folks that have taken the GRE Subject Exam in Biology: Is it absolutely necessary to take Biochemistry before tackling the exam, or can I study for the exam and still knock it out of the park? (specifics follow) [more inside]
posted by Ufez Jones on Oct 14, 2011 - 14 answers

Infectious hallucinations?

What would be the best way to create an infective agent that caused hallucinations? I was thinking a virus that modifed serotonin to psilocin - but how exactly would this take place in the cell, and how would a hypothetical virus catalyse that process? Is it realistic for a modern virology lab to design such a virus? I considered a bacterial vector, but I figure that bacterial infection of the CNS would probably just straight-up kill you due to the host response? Perhaps a bacterial species that just hangs out in your gut and squirts out psilocin that it synthesises itself, rather than having to methylate free serotonin? I know a fair bit of biochemistry but not much at all about microbiology, if that helps guide your explanations.
posted by nicolas léonard sadi carnot on Aug 26, 2011 - 19 answers

What did you do with your Biochemistry/Molecular Biology degree?

I'm looking for a sampling of where biochemistry students wind up after college. Basically, where did you start out and where did you end up? How difficult was it for you to find a position out of college? [more inside]
posted by WhitenoisE on Jun 21, 2011 - 8 answers

Chemistry + law = ?

I'm considering going to law school. I have BSs in chemistry and biochemistry. If I went, I'd like to end up practicing in an area where my scientific education is useful. Other than patent law, in what legal specialties would my background be helpful? [more inside]
posted by Gregor Samsa on Jun 13, 2011 - 10 answers

Also, I'm not to keen on working for free, either, unless that's not as outlandish a concept as I perceive it to be.

Thinking way, way ahead filter: I would like an industry internship for summer 2012, between the first and second year of my MSc in Biochemistry program. How do I go about securing it? [more inside]
posted by halogen on Apr 15, 2011 - 3 answers

Calling all biochemists!

Biochemistry filter: What do you consider the best evidence that would show a direct protein-protein interaction? [more inside]
posted by nasayre on Feb 21, 2011 - 17 answers

Getting off the ground with bioinformatics?

I'm a final year biochemistry undergrad, and through my internships / reading of papers / etc, I've become keenly aware that I'd like to be more conversant with computer science approaches to the field. The sheer volume of approaches and strategies in bioinformatics is a little overwhelming, though: where's a good place to start focusing my attention? I have strong maths skills, but my programming ability is limited to pecking out simple instruction sets in Python or Matlab, and my research work thus far has mostly been on isolating and characterising protein markers from serum / urine / etc.
posted by nicolas léonard sadi carnot on Nov 10, 2010 - 3 answers

Biochemistry Masters Program: Is a medical school environment worth it?

Biochemistry Masters Program: Is a medical school environment worth it? [more inside]
posted by anonymous on Jul 1, 2010 - 7 answers

Relative bond energies of common organic bonds

Looking for a chart or table that broadly summarizes/compares the relative bond energies of the most common intramolecular bonds found in organic molecules (think single and double bonds among C, H, O, N, and maybe S too). [more inside]
posted by killdevil on May 25, 2010 - 2 answers

...and then we'll take it higher.

Why do I feel electric currents? [more inside]
posted by kaseijin on May 17, 2010 - 22 answers

Looking for literature of life

Recommend me fascinating, intelligent and neutral reading regarding biology, biochemistry, or medicine. [more inside]
posted by Bleusman on May 15, 2010 - 21 answers

Help me google something!

Once I saw a drawing accompanying Jacques Monod's biochemical maxim "What is true of E. coli is true of the elephant." Can you help me find it again? [more inside]
posted by pullayup on Apr 13, 2010 - 1 answer

Biochemistry video?

I'm looking for a particular video clip of a CGI animation of a biochemical process. [more inside]
posted by darkstar on Mar 24, 2010 - 8 answers

Cause vs Effect

Are our feelings/emotions (love, anger, lust, sadness, etc.) a result of chemical reactions that take place in our body? Or do chemical reactions occur as a result of our emotional state? What comes first?
posted by murtagh on Mar 19, 2010 - 40 answers

There MUST be some way for me to do student research ...

My college's biological sciences dept has run out of student internship/research positions. The professors have emailed me back, saying that they might have openings in the spring. But I want to do something now. What are my other options? I'm in Los Angeles. [more inside]
posted by Xere on Sep 28, 2009 - 10 answers

I just want to work, for Christ's sake.

Why can't I find a job with my biochemistry bachelor's degree in Seattle, WA (grad school is most certainly on the agenda, but not for another couple of years)? What other options should I explore, and how do I go about it? [more inside]
posted by anonymous on Aug 22, 2009 - 16 answers

It's life, but not as we know it

Alternative-biochemistry-filter [more inside]
posted by kldickson on May 19, 2009 - 7 answers

Get me into grad school, please?

Another grad-school-after-poor-undergrad-grades question. What can I do to maximize my chances of being admitted to the grad school of my choice in the year before I apply? [more inside]
posted by anonymous on May 13, 2009 - 12 answers

The Cell-Molec Bio-Biochem subject GRE, and the vanquishing thereof

Help me knock the biochem/cell and molecular bio GRE out of the park! [more inside]
posted by palmcorder_yajna on Mar 24, 2009 - 9 answers

The Brain Chemistry of Reading

What is the brain chemistry involved in reading a good book? What areas of the brain are stimulated? What chemicals experience an uptick? Is there a particular combination unique to reading for pleasure? [more inside]
posted by SaharaRose on Feb 17, 2009 - 10 answers

How to get rid of gelatin?

Biochemists, cell biologists and assorted biotech types, what's your favorite method for removing gelatin from antibody solutions? No amines allowed! [more inside]
posted by Quietgal on May 27, 2008 - 3 answers

Biochemistry & Gene Therapy Filter

What's new and exciting in the fields of molecular biology, biochemistry, genetics? I'm looking for an exciting/interesting journal article to present to my classmates along the lines of heterologous eukaryotic expression of a gene or gene therapy utilizing knockouts as a technique or with an emphasis on transgenic organisms. I could, of course, slog through the journals on my own and guess at what might be exciting in the field, but I thought I would ask the hive first. Any biochemists or molecular biologists out there want to give this a go? Citations would be incredibly helpful.
posted by stuboo on Mar 18, 2008 - 13 answers

Practical sperm-wrangling

Speak to me of blocks to polyspermy. [more inside]
posted by palmcorder_yajna on Feb 24, 2008 - 3 answers

Why are magnets not bad?

Why does holding a strong magnet up to your brain not do anything bad? [more inside]
posted by zek on Aug 24, 2007 - 26 answers

siRNA woes

Attention Biochemists or Anyone Else working with RNAi-expressing cell lines: Help me troubleshoot! [more inside]
posted by LunaticFringe on Jan 4, 2007 - 15 answers

Lineweaver-burk woes.

BioChemistryFilter: How do I read the vMax and Km off of a Lineweaver-burk plot? [more inside]
posted by tnai on Feb 15, 2006 - 9 answers

Why is phosphorus so biologically important?

To the biochemists: what's so special about phosphorus? [more inside]
posted by feathermeat on Jan 22, 2006 - 10 answers

Will fasting metabolize "waste material" before healthy tissue?

"Within 24 hours of curtailing food intake, enzymes stop entering the stomach and travel instead into the intestines and into the bloodstream, where they circulate and gobble up all sorts of waste matter, including dead and damaged cells, unwelcome microbes, metabolic wastes, and pollutants." [cite] Could this possibly be true? I know that eventually the body will start metabolizing itself, but is the process selective in its initial stages to only metabolize "waste matter" and not healthy tissue?
posted by Asef Jil on Oct 3, 2005 - 19 answers

Biochem Jobs

What are the best jobs for a new graduate with a BS/MS in biochemistry? Looking for $$$, creative input, least-evil corporations. [+] [more inside]
posted by rxrfrx on Jan 13, 2005 - 10 answers

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