Cow jumps over Moon, details at eleven
February 26, 2008 7:21 AM
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I am asking this for my kids I am writing a book and researching what would happen (both physiologically and on a larger scope) if pure nitroglycerin were injected into a cow, which (as we all know) is just brimming over with methane? [NOT COWIST]
posted by misha to science & nature (13 comments total)
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MSDS for Nitroglycerin
The ACGIH limit is based on the risk of circulatory system effects .
HEALTH HAZARD INFORMATION
* Routes of Exposure
Exposure to nitroglycerin can occur through inhalation, ingestion, eye or skin contact, and absorption through the skin [Hathaway et al. 1991]
* Summary of toxicology
1. Effects on Animals: Nitroglycerin affects the cardiovascular system, blood, and nervous system of experimental animals. The dermal LD(50) in rabbits is greater than 280 mg/kg [NIOSH 1991]. The oral LD(50) in rats is 105 mg/kg [NIOSH 1991]. Animals administered nitroglycerin orally developed hypotension, tremors, ataxia, lethargy, hyperpnea, cyanosis, prostration and went into convulsions [NLM 1992]. Nitroglycerin has caused methemoglobinemia in dogs [NLM 1992].
2. Effects on Humans: Nitroglycerin is a vasodilator which affects the cardiovascular system, blood, and nervous system in humans [Hathaway et al. 1991]. Workers exposed to between 0.03 and 0.11 ppm complained of headaches and irritation [ACGIH 1991]. Chronic exposure results in the development of tolerance to the cardiovascular effects of nitroglycerin. A break in chronic exposure of one to three days can result in malaise, severe chest pains, palpatations, and even sudden death [Clayton and Clayton 1993; Rom 1992; NLM 1992]. Monday morning headaches or angina occur in chronically exposed workers as a result of a withdraw from exposure while not working over the weekend. Normally, if the individual is again exposed to nitroglycerin the symptoms will disappear. Exposure to nitroglycerin can also cause abnormalities of blood including methemoglobinemia and leukopenia. In addition, abnormal liver function tests have been observed in individuals exposed to nitroglycerin [Rom 1992]. Symptoms of Raynaud's phenomenon and peripheral neuropathy have also been reported in exposed workers [Rom 1992].
* Signs and symptoms of exposure
1. Acute exposure: Acute exposure to nitroglycerin can cause headaches, nausea, vomiting, occasionally diarrhea, sweating, and lightheadedness. High exposure can cause abdominal cramps, vomiting, depression or mania, mental confusion, delirium, convulsions, paresthesias or paralysis, aphasia, impaired vision, breathing difficulties, methemoglobinemia and blue skin (cyanosis), bradycardia, circulatory collapse, or death [Sittig 1991; Rom 1992].
2. Chronic exposure: Chronic exposure to nitroglycerin can lead to the development of tolerance, and sudden withdrawal from exposure can result in angina-like chest pains which may be accompanied by malaise, weakness, vomiting, dizziness, headache, or impaired vision. Sudden death may also result. Chronic exposure may also result in severe headache, hallucinations, and skin rashes. Allergic contact dermatitis can occur secondary to topical exposure to nitroglycerin.
posted by Comrade_robot at 7:23 AM on February 26, 2008