I grew up getting headaches, on average about one a month. Sometimes bad migraines, often just nasty headaches. I started drinking coffee a few years ago and have had one headache like that since. The change is incredible.posted by willbaude at 5:21 PM on December 19, 2012 [1 favorite]
The real reason caffeine aborts primary headacheI'm a couple drinks in and not really up to trying to understand what else might block those same receptors, but that might be a tack to take in your research.
According to the prevailing view, caffeine aborts caffeine withdrawal headache episodes by reversing caffeine withdrawal, but aborts migraine by some different, unidentified mechanism. Yet caffeine has only one known mechanism of action at likely doses: occupation and blockade of adenosine receptors. Caffeine must, therefore, relieve both caffeine withdrawal headache and migraine by blocking adenosine receptors. Caffeine's ability to abort migraine and other primary headaches provides insight into the causal mechanism of those headaches: evidently, adenosine receptor activation is an essential part of the causal mechanisms of both migraine and caffeine withdrawal headache.
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posted by 2bucksplus at 5:10 PM on December 19, 2012 [2 favorites]