This interaction was mainly driven by the fact that a moderate-to-high coffee intake was associated with lower breast volume in women with the C-allele. No association between coffee and breast volumes was observed in women with the CYP1A2*1F A/A genotype or in women who currently used hormonal contraception. As hormonal contraceptives lower the CYP1A2 enzyme activity (Rietveld et al, 1984), the latter observation was expected.And the conclusion:
In conclusion, the CYP1A2*1F genotype significantly modified the relationship between coffee consumption and breast volume in non-users of hormonal contraception. It is likely that various compounds in coffee exert a direct effect on the breast epithelium.So if you happen to have the right gene version, don't take oral contraceptives, don't already drink 3 cups of coffee a day, and can tolerate coffee, then starting to drink that much may have an effect. If you already drink that much coffee then drinking more won't do anything extra, it's a threshhold thing not a dose response curve. If you don't have the polymorphism then you're out of luck. The paper indicates a 50% chance of each although it's in a Swedish population, your allele frequencies myay vary. In none of these cases will taking the herbal pills you've linked have any effect, and they cost a lot more than coffee.
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In the meantime, your plan to strengthen your pectoral muscles (also work on core and back muscles) should make you more comfortable but if your breasts are truly out of proportion with the rest of your body, you may not be able to completely eliminate the stress they are putting on the rest of your body.
Good luck!
posted by ilikecookies at 1:37 PM on February 8 [3 favorites has favorites]